Isolated tumor cells in breast cancer


Isolated tumor cells in breast cancer sentinel lymph nodes: displacement or metastases? An immunohistochemical study. Sentinel lymph node isolated tumor cells as a group showed significantly lower expression of cyclin D1 and p53 compared with micro- and macrometastases. Purpose/Experimental Design: Immunocytochemical detection of isolated tumor cells (ITCs) in the bone marrow (BM) is a prognostic factor in breast cancer. However, hematopoietic cells (HCs) can occasionally be stained by the techniques used. Morphological evaluation improves the specificity of ITC. Circulating tumor cells from the blood of a breast cancer patient. Using the CTC-iChip, the researchers isolated CTCs from these samples and were able to establish cell lines from 6 of the patients. They found that 3 of 5 tested cell lines formed tumors when injected into mice. Isolated Cancer Cells May Lead to Personalized Treatments. Breast cancer patients with isolated tumor cells or small clusters of cancerous cells in their lymph nodes are less likely to survive and be disease free, but fare better after receiving additional treatment such as chemotherapy, radiation therapy, or hormone therapy, a Dutch study found.
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Topic: isolated tumor cell

Breast cancer patients with isolated tumor cells or small clusters of cancerous cells in their lymph nodes are less likely to survive and be disease free, but fare better after receiving additional treatment such as chemotherapy, radiation therapy, or hormone therapy, a Dutch study found. In this study, researchers evaluated whether isolated tumor cells (ITC) or micrometastases can predict survival in breast cancer patients and whether there is need for additional treatments in these patients. Dec 10,  · Breast Cancer Discussion Forums - Access the shared knowledge of thousands of people affected by breast cancer. Purpose/Experimental Design: Immunocytochemical detection of isolated tumor cells (ITCs) in the bone marrow (BM) is a prognostic factor in breast cancer. However, hematopoietic cells (HCs) can occasionally be stained by the techniques used. Morphological evaluation improves the specificity of ITC.
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The Prognostic Value of Isolated Tumor Cells in Bone Marrow in Breast Cancer Patients

Abstract BACKGROUND. In routine practice, the distinction between isolated tumor cells (ITC) and micrometastases (MIC) in patients with breast cancer is sometimes difficult to discern. Isolated tumor cells in breast cancer sentinel lymph nodes: displacement or metastases? An immunohistochemical study. Sentinel lymph node isolated tumor cells as a group showed significantly lower expression of cyclin D1 and p53 compared with micro- and macrometastases. SAN ANTONIO—Women with breast cancer who have isolated tumor cells or micrometastases in their sentinel lymph nodes are at increased risk for recurrence, even if their cancer otherwise has favorable features. Adjuvant systemic therapy, however, can attenuate that elevated risk, according to the. Circulating tumor cells from the blood of a breast cancer patient. Using the CTC-iChip, the researchers isolated CTCs from these samples and were able to establish cell lines from 6 of the patients. They found that 3 of 5 tested cell lines formed tumors when injected into mice. Isolated Cancer Cells May Lead to Personalized Treatments.
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Description:Abstract BACKGROUND. In routine practice, the distinction between isolated tumor cells (ITC) and micrometastases (MIC) in patients with breast cancer is sometimes difficult to discern. Breast cancer patients with isolated tumor cells or small clusters of cancerous cells in their lymph nodes are less likely to survive and be disease free, but fare better after receiving additional treatment such as chemotherapy, radiation therapy, or hormone therapy, a Dutch study found. Isolated tumor cells in breast cancer sentinel lymph nodes: displacement or metastases? An immunohistochemical study. Sentinel lymph node isolated tumor cells as a group showed significantly lower expression of cyclin D1 and p53 compared with micro- and macrometastases. Circulating tumor cells from the blood of a breast cancer patient. Using the CTC-iChip, the researchers isolated CTCs from these samples and were able to establish cell lines from 6 of the patients. They found that 3 of 5 tested cell lines formed tumors when injected into mice. Isolated Cancer Cells May Lead to Personalized Treatments.

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